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Price 60
caps x 40 mg - $60
Andriol is a
unique oral testosterone product, developed by the international
drug company Organon. One of the more
recently developed roids, Andriol first became available in the early 1980's.
Andriol contains 40 mg of testosterone undecanoate, based
in oil (oleic acid) and sealed inside a capsule. Subtracting the
ester weight, this equates to a dosage of approximately 25mg of
raw testosterone per cap. The design of
Andriol is quite
different from that of most oral roids. Drugs administered
orally generally enter the blood stream through the liver. When
a roids is given this way without some form of
structural protection, it will be quickly broken down during the
"first pass". This process leaves very little roids
intact, basically deactivating the drug. Adding a methyl group
(c-17 AA) to the structure is one way to protect it from this
process, however stress is also placed on the liver as a result.
In some instances this stress can lead to actual damage to liver
tissues, so the designers of those
roids sought another way to
protect the testosterone molecule. With Andriol, this was
accomplished by making a form of testosterone that would be
absorbed through the lymphatic system. This is due to its high
fat solubility brought about by the ester, and its suspension in
oil. Having Andriol absorbed this way was thought to be
very advantageous, as it allows roids
to bypass the destructive first-pass through liver. This should
permit Andriol to enter the blood stream intact, without
the need for a harsh chemical alteration. The ester breaks off
once it is in circulation of course, yielding free active
Pharmacokinetics of Oral Testosterone.
In design those roids appears
to be undecanoate that of a completely liver safe and orally
active form of testosterone.
On paper
Andriol seems like an ideal oral testosterone product. Clean, safe
and worlds apart from other oral testosterone derivatives like
the crude methyltestosterone. But as we always hear in life, if
it looks to good to be true, it probably is. And there are
definitely some issues with Andriol. The first problem is that
bioavailability, although clearly worlds apart from trying to
take straight testosterone orally, is probably not significant
next to c17alpha alkylated orals. Athletes typically find that
in doses of Andriol less than 240mg per day (6 capsules) effects are
generally not seen at all. 240mg of Andriol daily,
the primary male androgen, and only a meager effect. When doses
go higher, maybe 8-10 capsules (320-400mg), new muscle growth is
slight to moderate at best, but no incredible bulky gains are
ever reported. Logic leads one to think that only a little
testosterone is making its way into circulation. Testosterone is
a powerful hormone no matter what the ester or form of
administration. If it were active in the blood stream, the
results would have to be pronounced. When one injects an oil
based testosterone ester like cypionate, a dosage of 400mg per
week is more than sufficient. 400mg Andriol per day should be
packing on an incredible amount of mass. Where does it all go?
Individual problems with absorption may play into things here.
The graph above shows the median response noted when
Andriol
was given to a group of women. It does not however depict the
striking differences in individual metabolism that were noted in
this experiment. If we look at results from each of four
subjects, the differences are dramatic to say the least. While
one is off the scale with testosterone levels, another barely
budges at all. What is even more confusing is that results were
so inconsistent, that at times higher levels were achieved with
a lower 20 mg dose compared to the 40
mg when given to the same
subject. Clearly there is little to be said except that this
drug is unpredictable in its ability to be absorbed and utilized
by the body. While one day you might be getting great
absorption, perhaps the next day you are getting very little.
Studies with men were no better than with women, where again
this drug was shown to be unpredictably absorbed and utilized
with blood levels ranging from 11.5 to 60.1 nmol/L with 80mg
twice daily49.
One might also
pay interest to the "mildness" of
Andriol as described by
other bodybuilding materials. Andriol
® is often spoken about as
some type of magic product, which to spite being a form of
regular testosterone somehow allows for only minimal estrogen
conversion. You should know that the way a drug is administered
includes a number of factors that can slightly alter its effect,
the most predominant being the speed of release. This effects
the time it takes for a peak blood level to be reached, and
likely the length it takes to see results. The primary reason
Testosterone suspension seems more powerful than enanthate is
because more drug is active on day one. At the same time
estrogen builds up faster and side effects become pronounced
very quickly. The ester is also part of the total weight, and
100mg testosterone contains a much larger quantity of
testosterone molecules that testosterone plus ester, another
reason for varying effect. But these changes do not amount to
all that much. The structure of testosterone is what allows it
to break down into estrogen. The only way we can really prevent
an androgen from converting to estrogen is to change the base
molecule, not the ester. Once free in the blood stream we cannot
prevent testosterone from being aromatized without interfering
with the aromatase enzyme itself. The lack of results and side
effects often reported with Andriol ® must be going hand in hand
with poor absorption.
Most athletes
today consider Andriol a very poor buy. I know other references
do find use for Andriol, which is defendable because some
amount of roids clearly does enter the blood stream in tact.
Technically it is still an oral testosterone, and definitely
does not carry the same liver-toxicity risks associated with
most roids designed for this type of administration, so all
is not Post. Those specifically looking for a mild oral at times
do purchase this product, and occasionally are even satisfied
with their results. But for most its high price and required
high daily dosages usually causes them to avoided it when
crossing it on the black market. Besides, if we want a mild
roids the last thing we really should shop for is a
testosterone.
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